CB1-and CB2-type cannabinoid receptors mediate effects of the endocannabinoids 2-
arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid …

Abstract I (RPM) presented “The Year In G Protein-Coupled Receptor Research” at ENDO
2009. I first described the diversity of ligands and the five families into which the …

The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R–
MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic …

Coincidentally, the release of this Research Topic in Frontiers in Endocrinology takes place
25 years after the discovery of the adrenocorticotropic hormone receptor (ACTHR) by …

Melanocortin signalling is mediated by binding to a family of G protein-coupled receptors
that positively couple to adenylyl cyclase. Tetrapod species have five melanocortin (MC1 …

MRAP, melanocortin 2 (MC2) receptor accessory protein, is required for trafficking by the
MC2 (ACTH) receptor. MRAP is a single transmembrane protein that forms highly unusual …

The melanocortin 2 receptor (MC2R) accessory protein, MRAP, is one of a growing number
of G protein-coupled receptor accessory proteins that have been identified in recent years …

The functions of the phosphodiesterase 8B (PDE8) family of phosphodiesterases have been
largely unexplored because of the unavailability of selective pharmacological inhibitors …

G-protein-coupled receptors (GPCRs) are dynamically regulated by various mechanisms
that tune their response to external stimuli. Modulation of their plasma membrane density …

The activity of the hypothalamic-pituitary-adrenal axis is characterized by an ultradian
pulsatile pattern of glucocorticoid secretion. Despite increasing evidence for the importance …