Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single
blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful …

The cost of drug discovery and development is driven primarily by failure, with only about
10% of clinical programmes eventually receiving approval,–. We previously estimated that …

Abstract Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for
which the underlying biological mechanisms are not fully understood. In this study, we …

Polygenic scores (PGSs) have transformed human genetic research and have numerous
potential clinical applications. Here we present a series of recent enhancements to the PGS …

Abstract Type 2 diabetes (T2D) genome-wide association studies (GWASs) often overlook
rare variants as a result of previous imputation panels' limitations and scarce whole-genome …

Type 2 diabetes has long been thought to have heterogenous causes, even though
epidemiological studies uniformly show a tight relationship with overnutrition. The twin cycle …

Abstract Background Drug target Mendelian randomization describes the use of genetic
variants as instrumental variables for studying the effects of pharmacological agents. The …

Cancer and metabolic disorders have emerged as major global health challenges, reaching
epidemic levels in recent decades. Often viewed as separate issues, metabolic disorders …

Abstract Type 2 diabetes (T2D) is the fastest growing non-infectious disease worldwide.
Impaired insulin secretion from pancreatic beta-cells is a hallmark of T2D, but the …