Superior bifunctional chelating ligands, which can sequester both α-emitting radionuclides
(225Ac, 213Bi) and their diagnostic companions (155Tb, 111In), remain a formidable …

Abstract Positron Emission Tomography (PET) has emerged as a powerful imaging
technique in molecular medicine, enabling the non-invasive visualization and quantification …

The nuclear decay characteristics of 225Ac (E α= 5–8 MeV, linear energy transfer (LET)=∼
100 keV/μm, t 1/2= 9.92 days) are well recognized as advantageous for the treatment of …

8-Hydroxyquinoline (8-HQ, oxine) is a small, monoprotic, bicyclic aromatic compound and its
relative donor group orientation imparts impressive bidentate metal chelating abilities that …

A new, bifunctional chelating ligand for immuno-Positron Emission Tomography (PET) was
designed, synthesized, and conjugated to Trastuzumab for a proof-of-concept study with 89 …

A new versatile chelating ligand for intermediate size and softness radiometals [64Cu] Cu2+
and [111In] In3+, H2pyhox, was synthesized by introducing pyridine as a new donor moiety …

H4pypa is a nonadentate nonmacrocyclic chelator, which previously demonstrated high
affinity for scandium-44, lutetium-177, and indium-111. Herein, we report the highly stable …

With the interest in radiometal-containing diagnostic and therapeutic pharmaceuticals
increasing rapidly, appropriate ligands to coordinate completely and stably said radiometals …

Advances in nuclear medicine include new chelating ligands that form highly stable and
kinetically inert complexes with relevant radiometal ions for use in diagnosis or therapy …

Radiometal-based pharmaceuticals have emerged as powerful clinical tools which can
achieve both diagnostic imaging and targeted therapy of disease and have become crucial …