Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

TP53 is the most frequently mutated gene in breast cancer, but its role in survival is
confounded by different studies concluding that TP53 mutations are associated with …

The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Resistance exists against every effective anticancer …

Oncogenic Ras and p53 loss-of-function mutations are common in many advanced sporadic
malignancies and together predict a limited responsiveness to conventional chemotherapy …

Background: Molecular profiling has identified at least four subtypes of invasive breast
carcinoma, which exhibit distinct clinical behaviour. There is good evidence now that DCIS …

Background In breast cancers, only a minority of patients fully benefit from the different
chemotherapy regimens currently in use. Identification of markers that could predict the …

Background Ion channels play a critical role in a wide variety of biological processes,
including the development of human cancer. However, the overall impact of ion channels on …

Background Breast cancer consists of a variety of tumours, which differ by their
morphological features, molecular characteristics and outcome. Well-known prognostic …

Despite its central role in the control of apoptosis, senescence and cell cycle arrest, the
tumor suppressor protein p53 remains an enigma for its possible role in predicting response …

Introduction 3. Drug influx/efflux 3.1. Drug influx 3.2. Drug efflux 4. Drug activation and
inactivation 4.1. Drug activation 4.2. Drug inactivation 5. DNA damage repair 5.1. DNA …