The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlap** …

Investigation of the hippocampus has historically focused on computations within the
trisynaptic circuit. However, discovery of important anatomical and functional variability …

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus
challenge the long-standing hypothesis that hippocampal long-term potentiation-like …

The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and …

Information that is congruent with existing knowledge (a schema) is usually better
remembered than less congruent information. Only recently, however, has the role of …

Abstract Changes in memory performance are one of the hallmark symptoms of mild
cognitive impairment and are affected by healthy aging as well. Pattern separation, which …

Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

Every day people make new choices between alternatives that they have never directly
experienced. Yet, such decisions are often made rapidly and confidently. Here, we show that …

Examine the basic principles of differentiation in light of what current research on
educational neuroscience has revealed. This research pool offers information and insights …

The hippocampal formation is one of the most extensively studied regions of the brain, with
well-described anatomy and basic physiology; moreover, aspects of human memory …