Specialized membrane domains are an important feature of almost all cells. In particular,
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …

Cell-adhesion molecules, once believed to function primarily in tethering cells to
extracellular ligands, are now recognized as having broader functions in cellular signalling …

It is well established that the large array of functions that a tumour cell has to fulfil to settle as
a metastasis in a distant organ requires cooperative activities between the tumour and the …

The peripheral astrocyte process (PAP) preferentially associates with the synapse. The PAP,
which is not found around every synapse, extends to or withdraws from it in an activity …

Patients presenting with metastatic rhabdomyosarcoma (RMS), the most common soft-tissue
sarcoma in children, have a very poor clinical prognosis. This is due, in large part, to our …

Ezrin, a membrane–actin cytoskeleton linker, which participates in epithelial cell
morphogenesis, is held inactive in the cytoplasm through an intramolecular interaction …

A wide variety of soluble signaling substances utilize the cyclic AMP-dependent protein
kinase (PKA) pathway to regulate cellular behaviors including intermediary metabolism, ion …

The major glial population of the brain is constituted by astroglia. Highly branched and
ramified protoplasmic astrocytes are the predominant form in grey matter and are found in …

CD44 is a widely distributed type I transmembrane glycoprotein and functions as the major
hyaluronan receptor on most cell types. Although alternative splicing can produce a large …

The phenomenon of cell cannibalism, which generally refers to the engulfment of cells within
other cells, was described in malignant tumors, but its biological significance is still largely …