Drug-membrane interactions: significance for medicinal chemistry

M Lucio, J Lima, S Reis - Current medicinal chemistry, 2010 - ingentaconnect.com
Generally drugs can act on the level of different biological membranes as well as inside the
cells that are limited by membranes. Even in the latter situation, drugs must still interact with …

Interaction of nonsteroidal anti-inflammatory drugs with membranes: in vitro assessment and relevance for their biological actions

C Pereira-Leite, C Nunes, S Reis - Progress in lipid research, 2013 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs
in the world due to their anti-inflammatory, analgesic and antipyretic properties …

Biomembrane models and drug-biomembrane interaction studies: Involvement in drug design and development

R Pignatello, T Musumeci, L Basile… - Journal of pharmacy …, 2011 - journals.lww.com
Contact with many different biological membranes goes along the destiny of a drug after its
systemic administration. From the circulating macrophage cells to the vessel endothelium, to …

Shedding light on the puzzle of drug-membrane interactions: Experimental techniques and molecular dynamics simulations

D Lopes, S Jakobtorweihen, C Nunes… - Progress in lipid …, 2017 - Elsevier
Lipid membranes work as barriers, which leads to inevitable drug-membrane interactions in
vivo. These interactions affect the pharmacokinetic properties of drugs, such as their …

Mitochondrial membrane lipid remodeling in pathophysiology: a new target for diet and therapeutic interventions

JP Monteiro, PJ Oliveira, AS Jurado - Progress in lipid research, 2013 - Elsevier
Mitochondria are arbiters in the fragile balance between cell life and death. These
organelles present an intricate membrane system, with a peculiar lipid composition and …

Label-free spectroscopic detection of membrane potential using stimulated Raman scattering

B Liu, HJ Lee, D Zhang, CS Liao, N Ji, Y **a… - Applied Physics …, 2015 - pubs.aip.org
Hyperspectral stimulated Raman scattering microscopy is deployed to measure single-
membrane vibrational spectrum as a function of membrane potential. Using erythrocyte …

Structural association of nonsteroidal anti-inflammatory drugs with lipid membranes

MB Boggara, M Mihailescu… - Journal of the American …, 2012 - ACS Publications
The location and distribution of ibuprofen, a model nonsteroidal anti-inflammatory drug, in a
phospholipid bilayer was examined in molecular detail by a combination of neutron …

Structural similarity with cholesterol reveals crucial insights into mechanisms sustaining the immunomodulatory activity of the mycotoxin alternariol

G Del Favero, RM Mayer, L Dellafiora, L Janker… - Cells, 2020 - mdpi.com
The proliferation of molds in domestic environments can lead to uncontrolled continuous
exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic …

Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/β-catenin signaling while up-regulating ligand …

MK Saini, SN Sanyal - Biomedicine & Pharmacotherapy, 2014 - Elsevier
The colon cancer tissues from DMH treated rats exhibited higher membrane potential,
fluidity and changed lipid order as examined by Merocyanine 540 and 1, 6-diphenyl-1, 3, 5 …

[HTML][HTML] Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology

VC Lombardi, SF Khaiboullina - Clinical immunology, 2014 - Elsevier
Plasmacytoid dendritic cells (pDCs) are bone marrow-derived immune cells with the ability
to express copious amounts of type I and III interferon (IFN) and can differentiate into antigen …