Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and develo** cancer immunotherapies. Recent applications of …

Interaction between tumor cells and immune cells in the tumor microenvironment is
important in cancer development. Immune cells interact with the tumor cells to shape this …

Hepatocellular Carcinoma (HCC) is one of the most common types of primary liver cancer.
Current treatment options have limited efficacy against this malignancy, primarily owing to …

With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

Heterogeneity describes the differences among cancer cells within and between tumors. It
refers to cancer cells describing variations in morphology, transcriptional profiles …

Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …

Hepatocarcinogenesis involves complex genetic and cellular dysregulations which drive the
formation of hepatocellular carcinoma (HCC), the predominant form of primary liver cancer …

Unsatisfied clinical outcome drives to better understand hepatic carcinogenesis,
microenvironment and escape of immune surveillance in hepatocellular carcinoma (HCC) …