Transport selectivity of nuclear pores, phase separation, and membraneless organelles
Nuclear pore complexes (NPCs) provide a selective passageway for receptor-mediated
active transport between nucleus and cytoplasm, while maintaining the distinct molecular …
active transport between nucleus and cytoplasm, while maintaining the distinct molecular …
The structure and dynamics of higher-order assemblies: amyloids, signalosomes, and granules
We here attempt to achieve an integrated understanding of the structure and dynamics of a
number of higher-order assemblies, including amyloids, various kinds of signalosomes, and …
number of higher-order assemblies, including amyloids, various kinds of signalosomes, and …
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …
Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export
The toxic proline: arginine (PRn) poly-dipeptide encoded by the (GGGGCC) n repeat
expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the …
expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the …
Systematic analysis of barrier‐forming FG hydrogels from Xenopus nuclear pore complexes
AA Labokha, S Gradmann, S Frey, BB Hülsmann… - The EMBO …, 2013 - embopress.org
Nuclear pore complexes (NPCs) control the traffic between cell nucleus and cytoplasm.
While facilitating translocation of nuclear transport receptors (NTRs) and NTR· cargo …
While facilitating translocation of nuclear transport receptors (NTRs) and NTR· cargo …
Protein disorder, prion propensities, and self-organizing macromolecular collectives
Eukaryotic cells are partitioned into functionally distinct self-organizing compartments. But
while the biogenesis of membrane-surrounded compartments is beginning to be …
while the biogenesis of membrane-surrounded compartments is beginning to be …
Phase separation of intrinsically disordered FG-Nups is driven by highly dynamic FG motifs
The intrinsically disordered FG-Nups in the central channel of the nuclear pore complex
(NPC) form a selective permeability barrier, allowing small molecules to traverse by passive …
(NPC) form a selective permeability barrier, allowing small molecules to traverse by passive …
Improving the hole picture: towards a consensus on the mechanism of nuclear transport
Nuclear pore complexes (NPCs) mediate the exchange of materials between the
nucleoplasm and cytoplasm, playing a key role in the separation of nucleic acids and …
nucleoplasm and cytoplasm, playing a key role in the separation of nucleic acids and …
Disordered proteinaceous machines
Many full-length proteins and protein regions lack stable tertiary and/or secondary structure
under physiological conditions in vitro. These proteins and regions, known as intrinsically …
under physiological conditions in vitro. These proteins and regions, known as intrinsically …
Protein assembly systems in natural and synthetic biology
The traditional view of protein aggregation as being strictly disease-related has been
challenged by many examples of cellular aggregates that regulate beneficial biological …
challenged by many examples of cellular aggregates that regulate beneficial biological …