Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour
The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …
their pathophysiological roles are increasingly the subject of investigation. Evidence …
[PDF][PDF] Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women
Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …
[HTML][HTML] Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes
L Gu, Y Ma, M Gu, Y Zhang, S Yan, N Li, Y Wang… - Peptides, 2015 - Elsevier
Spexin mRNA and protein are widely expressed in rat tissues and associate with weight loss
in rodents of diet-induced obesity. Its location in endocrine and epithelial cells has also been …
in rodents of diet-induced obesity. Its location in endocrine and epithelial cells has also been …
Adipose–Muscle crosstalk in age-related metabolic disorders: The emerging roles of adipo-myokines
P Fang, Y She, M Yu, W Min, W Shang… - Ageing Research Reviews, 2023 - Elsevier
Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …
Neuropeptide and small transmitter coexistence: fundamental studies and relevance to mental illness
Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …
Spexin inhibits excessive autophagy‐induced ferroptosis to alleviate doxorubicin‐induced cardiotoxicity by upregulating Beclin 1
W Ou, H Liu, C Chen, C Yang, X Zhao… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Doxorubicin is widely used in the treatment of malignant
tumours, but doxorubicin‐induced cardiotoxicity severely limits its clinical application …
tumours, but doxorubicin‐induced cardiotoxicity severely limits its clinical application …
[HTML][HTML] 30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and …
Spexin (SPX) is a 14 aa peptide discovered in 2007 using bioinformatics methods. SPX
inhibits food intake and regulates lipid, and carbohydrate metabolism. Here, we evaluate the …
inhibits food intake and regulates lipid, and carbohydrate metabolism. Here, we evaluate the …
Description and functional validation of human enteroendocrine cell sensors
Enteroendocrine cells (EECs) are gut epithelial cells that respond to intestinal contents by
secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric …
secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric …
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Peptide hormones and neuropeptides are complex signaling molecules that predominately
function through G protein-coupled receptors (GPCRs). Two unanswered questions …
function through G protein-coupled receptors (GPCRs). Two unanswered questions …