Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Aging is a complex process with an impact on essentially all organs. Declined cellular repair
causes increased damage at genomic and proteomic levels upon aging. This can lead to …

Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the
hydrolysis of triglycerides, declines with age,. The defect in the mobilization of free fatty acids …

While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in
physiological cardiac aging is largely unknown. During aging, many alterations occur in the …

Recent studies have revealed novel forms of cell death beyond the canonical types of
cellular apoptosis and necrosis, and these novel forms of cell death are induced by extreme …

During aging, visceral adiposity is often associated with alterations in adipose tissue (AT)
leukocytes, inflammation, and metabolic dysfunction. However, the contribution of AT B cells …

Aims Inflammation plays an important role in cardiovascular disease (CVD) development.
The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of …

Senescence is a cellular program that prevents the replication of old, damaged, or
cancerous cells. Senescent cells become growth arrested and undergo changes in their …

Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for
normal postnatal growth and has pleiotropic effects across multiple physiological systems …

Since its discovery nearly a century ago, over 100,000 studies of growth hormone (GH) have
investigated its structure, how it interacts with the GH receptor and its multiple actions. These …