Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

Optogenetics ushered in a revolution in how neuroscientists interrogate brain function.
Because of technical limitations, the majority of optogenetic studies have used low spatial …

Genetically encoded voltage indicators (GEVIs) enable optical recording of electrical signals
in the brain, providing subthreshold sensitivity and temporal resolution not possible with …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Recent studies have shown that neuronal representations gradually change over time
despite no changes in the stimulus, environment, or behavior. However, such …

Progress in many scientific disciplines is hindered by the presence of independent noise.
Technologies for measuring neural activity (calcium imaging, extracellular electrophysiology …

Calcium imaging with fluorescent protein sensors is widely used to record activity in
neuronal populations. The transform between neural activity and calcium-related …

Nullius in verba ('trust no one'), chosen as the motto of the Royal Society in 1660, implies
that independently verifiable observations—rather than authoritative claims—are a defining …

Monitoring spiking activity across large neuronal populations at behaviorally relevant
timescales is critical for understanding neural circuit function. Unlike calcium imaging …