Schizophrenia, autism and intellectual disabilities are best understood as spectrums of
diseases that have broad sets of causes. However, it is becoming evident that these …

The discovery of the genetic causes of syndromic autism spectrum disorders and intellectual
disabilities has greatly informed our understanding of the molecular pathways critical for …

Mutations in the X-linked MECP2 gene, which encodes the transcriptional regulator methyl-
CpG-binding protein 2 (MeCP2), cause Rett syndrome and several neurodevelopmental …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the X-linked
gene MECP2 (methyl-CpG-binding protein 2). Two decades of research have fostered the …

Rett syndrome (RTT) is a severe, progressive, neurodevelopmental disorder, which affects
predominantly females. In most cases, RTT is associated with pathogenic variants in …

BACKGROUND Neurodevelopmental disorders are caused by abnormalities in the
develo** brain. Such abnormalities can occur as a result of germline or somatic mutations …

Rett syndrome (RTT) is a neurological disorder caused by mutations in the X-linked gene
methyl-CpG-binding protein 2 (MECP2), a ubiquitously expressed transcriptional regulator …

Rett's syndrome (RTT) is an X-chromosome-linked autism spectrum disorder caused by loss
of function of the transcription factor methyl-CpG-binding protein 2 (MeCP2). Although …

Stressful events during adulthood are potent adverse environmental factors that can
predispose individuals to psychiatric disorders, including depression; however, many …

Rett Syndrome (RTT) is a severe form of X-linked mental retardation caused by mutations in
the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a …