The liver consists of two types of epithelial cells: hepatocytes, which represent 60% to 70%
of the liver cell population (l), or 90% of total liver mass (2); and intrahepatic bile duct …

Maintenance of tolerance to self antigens is presumed to reflect a combination of central and
peripheral tolerance. For T cells, central tolerance occurs during early T cell development in …

Abstract Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in
normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules …

CD28 and CTLA-4 are related glycoproteins found on T cells. Ligation of CD28 following
antigen receptor engagement provides a costimulatory signal required for T cell activation …

We have resolved B220+ IgM-B-lineage cells in mouse bone marrow into four fractions
based on differential cell surface expression of determinants recognized by S7 (leukosialin …

Neonatal thymectomy (NTx), especially around day 3 after birth, causes various organ-
specific autoimmune diseases in mice. This report shows that:(a) T cells expressing the …

CTLA-4 is a CD28 homologue believed to be a negative regulator of T cell function.
However, the mechanism of this downregulatory activity is not well understood. The present …

Human follicular 6 cell lymphomas possess at (14; 18) interchromosomal translocation that
juxtaposes the putative proto-oncogene bcl-2 with the immunoglobulin (lg) heavy chain …

We have used retrovirus-mediated gene transfer to mark hematopoietic stem cells in vitro
and have tracked the fate of these cells after their transplantation into lethally irradiated …

The continuously proliferating clones L/B AgA2, CB/Bm 7, Ba/C1, and Bc/Bm 11 were
established from bone marrow of MRL/LPR, CBA/J, and BALB/c mice. These clones carry …