IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …

Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …

Crohn's disease is a chronic inflammatory intestinal disease that is frequently accompanied
by aberrant healing and stricturing complications. Crosstalk between activated myeloid and …

The structure-based design introduced indoles as an essential motif in designing new
selective estrogen receptor modulators employed for treating breast cancer. Therefore, here …

Simple Summary Many signaling pathways are overactive in breast cancer, and among
them is the STAT3 signaling pathway. STAT3 is activated by secreted factors within the …

Drug repurposing is a valuable approach in delivering new cancer therapeutics rapidly into
the clinic. Existing safety and patient tolerability data for drugs already in clinical use …

Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11,
contributes to disease progression and poor survival outcomes in patients with colorectal …

SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins
encoded in its genome. Their roles during infection are still not completely understood. In …

Interleukin‐6 (IL‐6) is an inflammatory cytokine, the level of which is highly elevated in most,
if not all, inflammatory states. IL‐6 triggers cell type‐specific responses and acts on target …

Interleukin-11 is a cytokine from the IL-6 family of cytokines that includes IL-6 and oncostatin-
M. Initially described for its role in platelet generation, it is now appreciated that this cytokine …