Ionic liquids: new forms of active pharmaceutical ingredients with unique, tunable properties

JL Shamshina, RD Rogers - Chemical Reviews, 2023 - ACS Publications
This Review aims to summarize advances over the last 15 years in the development of
active pharmaceutical ingredient ionic liquids (API-ILs), which make up a prospective game …

Solid-state NMR spectroscopy

B Reif, SE Ashbrook, L Emsley, M Hong - Nature Reviews Methods …, 2021 - nature.com
Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to
determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This …

Synergistic effect of hydrogen bonding and π–π stacking enables long cycle life in organic electrode materials

MR Tuttle, ST Davis, S Zhang - ACS Energy Letters, 2021 - ACS Publications
Small-molecule organic compounds have emerged as attractive candidates for energy
storage in lithium-ion batteries because of their sustainability and modularity. To develop …

Pharmaceutical applications of lidocaine-based ionic liquids–a remarkable innovation in drug delivery

B Mir, S Naz, M Uroos, B Ali, F Sharif - Journal of Molecular Liquids, 2024 - Elsevier
Over the last few decades, there has been a growing interest in develo** innovative drug
delivery approaches that can assist drug release to attain the vital extent of therapeutic …

Improving the shale stability with nano-silica grafted with hyperbranched polyethyleneimine in water-based drilling fluid

H Zhong, X Gao, X Zhang, Z Qiu, C Zhao… - Journal of Natural Gas …, 2020 - Elsevier
Shale hydration and dispersion leading to wellbore instability is always a challenge in oil
and gas drilling engineering. In this study, specifically designed nano-particles by grafting …

Halogen bonding regulated functional nanomaterials

J Zheng, A Suwardi, CJE Wong, XJ Loh, Z Li - Nanoscale Advances, 2021 - pubs.rsc.org
Non-covalent interactions have gained increasing attention for use as a driving force to
fabricate various supramolecular architectures, exhibiting great potential in crystal and …

Atomic-level drug substance and polymer interaction in posaconazole amorphous solid dispersion from solid-state NMR

X Lu, M Li, C Huang, MB Lowinger, W Xu… - Molecular …, 2020 - ACS Publications
Despite the wide utilization of amorphous solid dispersions (ASDs) for formulating poorly
water-soluble drugs, fundamental understanding of the structural basis behind their stability …

Unravelling the nature of citric acid: l-arginine: water mixtures: the bifunctional role of water

A Roda, F Santos, YZ Chua, A Kumar, HT Do… - Physical Chemistry …, 2021 - pubs.rsc.org
The use of water as a component of deep eutectic systems (DES) has raised some
questions regarding its influence on the nature of the mixture. Does it form a DES or an …

Structural evaluation of the choline and geranic acid/water complex by SAXS and NMR analyses

J Takeda, Y Iwao, M Karashima… - ACS Biomaterials …, 2021 - ACS Publications
Recently, choline and geranic acid (CAGE), an ionic liquid (IL), has been recognized to be a
superior biocompatible material for oral and transdermal drug delivery systems (DDS) …

Understanding molecular interactions in rafoxanide–povidone amorphous solid dispersions from ultrafast magic angle spinning NMR

M Li, F Meng, Y Tsutsumi, JP Amoureux… - Molecular …, 2020 - ACS Publications
In solid dosage formulations, probing intermolecular interactions between active
pharmaceutical ingredients (APIs) and polymeric excipients, which have a mechanistic …