Inflammation and oxidative stress in chronic kidney disease and dialysis patients
Significance: Chronic kidney disease (CKD) can be regarded as a burden of lifestyle
disease that shares common underpinning features and risk factors with the aging process; …
disease that shares common underpinning features and risk factors with the aging process; …
Chronic kidney disease and premature ageing
Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic
diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and …
diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and …
Klotho in clinical nephrology: diagnostic and therapeutic implications
Abstract αKlotho (called Klotho here) is a membrane protein that serves as the coreceptor for
the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and …
the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and …
α-Klotho expression in human tissues
Context: α-Klotho has emerged as a powerful regulator of the aging process. To date, the
expression profile of α-Klotho in human tissues is unknown, and its existence in some …
expression profile of α-Klotho in human tissues is unknown, and its existence in some …
[HTML][HTML] Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies
Klotho is a membrane-bound protein predominantly expressed in the kidney, where it acts
as a permissive co-receptor for Fibroblast Growth Factor 23. In its shed form, Klotho exerts …
as a permissive co-receptor for Fibroblast Growth Factor 23. In its shed form, Klotho exerts …
[HTML][HTML] Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease
Q Zhang, L Liu, W Lin, S Yin, A Duan, Z Liu, W Cao - Kidney international, 2017 - Elsevier
Rhein is an anthraquinone compound isolated from the medicinal plant rhubarb and mainly
used in the clinical treatment of diabetic nephropathy. Rhein exhibits various renoprotective …
used in the clinical treatment of diabetic nephropathy. Rhein exhibits various renoprotective …
Association of serum Klotho levels with cancer and cancer mortality: Evidence from National Health and Nutrition Examination Survey
Y Qiao, F Liu, Y Peng, P Wang, B Ma, L Li… - Cancer …, 2023 - Wiley Online Library
Background Klotho has both anticancer and hormone‐like functions. But the research on
Klotho and cancer is mainly based on animal experiments and small‐scale clinical research …
Klotho and cancer is mainly based on animal experiments and small‐scale clinical research …
[HTML][HTML] TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis
S Yin, Q Zhang, J Yang, W Lin, Y Li, F Chen… - Biochimica et Biophysica …, 2017 - Elsevier
Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD) and its
development and progression are significantly affected by epigenetic modifications such as …
development and progression are significantly affected by epigenetic modifications such as …
[HTML][HTML] Klotho restoration via acetylation of peroxisome proliferation–activated receptor γ reduces the progression of chronic kidney disease
W Lin, Q Zhang, L Liu, S Yin, Z Liu, W Cao - Kidney international, 2017 - Elsevier
Klotho is an anti-aging protein mainly expressed in the kidney. Reduced Klotho expression
closely correlates with the development and progression of chronic kidney disease (CKD) …
closely correlates with the development and progression of chronic kidney disease (CKD) …
Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease
Klotho is a renal protein involved in phosphate homeostasis, which is downregulated in
renal disease. It has long been considered an antiaging factor. Two Klotho gene transcripts …
renal disease. It has long been considered an antiaging factor. Two Klotho gene transcripts …