Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense
RNA genome that can cause serious illness in humans and animals. The 11 kb 5′ capped …

Ticks transmit more pathogens to humans and animals than any other arthropod. We
describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors …

Drosophila melanogaster is a valuable invertebrate model for viral infection and antiviral
immunity, and is a focus for studies of insect-virus coevolution. Here we use a metagenomic …

Background The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously
obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health …

The ectoparasitic mite Varroa destructor is the leading threat to the health of Western honey
bees (Apis mellifera) primarily through its action as a vector of viruses. However, it is unclear …

Canonical RNAi, one of the so-called RNA-silencing mechanisms, is defined as sequence-
specific RNA degradation induced by long double-stranded RNA (dsRNA). RNAi occurs in …

The common feature of flaviviral infection is the accumulation of abundant virus-derived
noncoding RNA, named flaviviral subgenomic RNA (sfRNA) in infected cells. This RNA …

Hundreds of viruses, designated as arboviruses, are transmitted by arthropod vectors in
complex transmission cycles between the virus, vertebrate host, and the vector. With millions …

RNA interference (RNAi) was shown over 18 years ago to be a mechanism by which
arbovirus replication and transmission could be controlled in arthropod vectors. During the …