[HTML][HTML] Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients …

MR Lewin, RW Carter, IA Matteo, SP Samuel, S Rao… - Toxins, 2022 - mdpi.com
The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …

[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming

JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell… - Toxins, 2021 - mdpi.com
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

LO Albulescu, C **e, S Ainsworth, J Alsolaiss… - Nature …, 2020 - nature.com
Snakebite is a medical emergency causing high mortality and morbidity in rural tropical
communities that typically experience delayed access to unaffordable therapeutics. Viperid …

The BRAVO clinical study protocol: oral varespladib for inhibition of secretory phospholipase A2 in the treatment of snakebite envenoming

RW Carter, CJ Gerardo, SP Samuel, S Kumar… - toxins, 2022 - mdpi.com
Introduction: Snakebite is an urgent, unmet global medical need causing significant
morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory …

Snake antivenom: Challenges and alternate approaches

A Alangode, K Rajan, BG Nair - Biochemical Pharmacology, 2020 - Elsevier
Snake envenomation is still a serious threat to many countries in the world. The only
mainstay treatment depends on the administration of animal derived immunoglobulin based …

[HTML][HTML] Clinical management of snakebite envenoming: future perspectives

M Hamza, C Knudsen, CA Gnanathasan, W Monteiro… - Toxicon: X, 2021 - Elsevier
Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …

[HTML][HTML] Biosynthetic oligoclonal antivenom (BOA) for snakebite and next-generation treatments for snakebite victims

RM Kini, SS Sidhu, AH Laustsen - Toxins, 2018 - mdpi.com
Snakebite envenoming is a neglected tropical disease that each year claims the lives of
80,000–140,000 victims worldwide. The only effective treatment against envenoming …

[HTML][HTML] Amplification of snake venom toxicity by endogenous signaling pathways

PE Bickler - Toxins, 2020 - mdpi.com
The active components of snake venoms encompass a complex and variable mixture of
proteins that produce a diverse, but largely stereotypical, range of pharmacologic effects and …

Small molecule drug discovery for neglected tropical snakebite

RH Clare, SR Hall, RN Patel, NR Casewell - Trends in pharmacological …, 2021 - cell.com
Snakebite envenoming is responsible for as many as 138 000 deaths annually, making it the
world's most lethal neglected tropical disease (NTD). There is an urgent need to improve …

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

SR Hall, SA Rasmussen, E Crittenden… - Nature …, 2023 - nature.com
Morbidity from snakebite envenoming affects approximately 400,000 people annually.
Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is …