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[HTML][HTML] Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients …
MR Lewin, RW Carter, IA Matteo, SP Samuel, S Rao… - Toxins, 2022 - mdpi.com
The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …
[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
LO Albulescu, C **e, S Ainsworth, J Alsolaiss… - Nature …, 2020 - nature.com
Snakebite is a medical emergency causing high mortality and morbidity in rural tropical
communities that typically experience delayed access to unaffordable therapeutics. Viperid …
communities that typically experience delayed access to unaffordable therapeutics. Viperid …
The BRAVO clinical study protocol: oral varespladib for inhibition of secretory phospholipase A2 in the treatment of snakebite envenoming
RW Carter, CJ Gerardo, SP Samuel, S Kumar… - toxins, 2022 - mdpi.com
Introduction: Snakebite is an urgent, unmet global medical need causing significant
morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory …
morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory …
Snake antivenom: Challenges and alternate approaches
Snake envenomation is still a serious threat to many countries in the world. The only
mainstay treatment depends on the administration of animal derived immunoglobulin based …
mainstay treatment depends on the administration of animal derived immunoglobulin based …
[HTML][HTML] Clinical management of snakebite envenoming: future perspectives
Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …
[HTML][HTML] Biosynthetic oligoclonal antivenom (BOA) for snakebite and next-generation treatments for snakebite victims
Snakebite envenoming is a neglected tropical disease that each year claims the lives of
80,000–140,000 victims worldwide. The only effective treatment against envenoming …
80,000–140,000 victims worldwide. The only effective treatment against envenoming …
[HTML][HTML] Amplification of snake venom toxicity by endogenous signaling pathways
PE Bickler - Toxins, 2020 - mdpi.com
The active components of snake venoms encompass a complex and variable mixture of
proteins that produce a diverse, but largely stereotypical, range of pharmacologic effects and …
proteins that produce a diverse, but largely stereotypical, range of pharmacologic effects and …
Small molecule drug discovery for neglected tropical snakebite
Snakebite envenoming is responsible for as many as 138 000 deaths annually, making it the
world's most lethal neglected tropical disease (NTD). There is an urgent need to improve …
world's most lethal neglected tropical disease (NTD). There is an urgent need to improve …
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms
SR Hall, SA Rasmussen, E Crittenden… - Nature …, 2023 - nature.com
Morbidity from snakebite envenoming affects approximately 400,000 people annually.
Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is …
Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is …