Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Obesity, a social problem worldwide, is characterized by an increase in body weight that
results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and …

Obesity is a chronic disease of multifactorial origin and can be defined as an increase in the
accumulation of body fat. Adipose tissue is not only a triglyceride storage organ, but studies …

Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines
may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are …

The recent discovery that hydrogen sulfide (H2S) is an endogenously produced gaseous
second messenger capable of modulating many physiological processes, much like nitric …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Obesity reaches up to epidemic proportions globally and increases the risk for a wide
spectrum of co-morbidities, including type-2 diabetes mellitus (T2DM), hypertension …

Obesity is currently one of the major epidemics of this millennium and affects individuals
throughout the world. It causes multiple systemic complications, some of which result in …

Diabetic nephropathy is the leading cause of end‐stage kidney disease worldwide but
current treatments remain suboptimal. This review examines the evidence for inflammation …