DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …

Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …

Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

The establishment of cell identity during embryonic development involves the activation of
specific gene expression programmes and is underpinned by epigenetic factors including …

The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid
base damage, DNA strand breakage, inter-and intra-strand cross-linking of nucleic acids …

G-quadruplexes (G4s) are peculiar nucleic acid secondary structures formed by DNA or
RNA and are considered as fundamental features of the genome. Many proteins can …

Abstract G-quadruplex (G4) structures have been predicted in the genomes of many
organisms and proven to play regulatory roles in diverse cellular activities. However, there is …

The role of non-duplex DNA, the guanine-quadruplex structure in particular, is becoming
widely appreciated. Increasing evidence in the last decade implicates quadruplexes in …

Aging is a prominent risk factor for many neurodegenerative disorders, such as Alzheimer's
disease (AD). Alzheimer's disease is characterized by progressive cognitive decline …