Interplay between food and gut microbiota in health and disease
NB Danneskiold-Samsøe, HDFQ Barros… - Food research …, 2019 - Elsevier
Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in
relation to digestion and absorption of dietary components. They biotransform food …
relation to digestion and absorption of dietary components. They biotransform food …
A novel perspective on the biology of bilirubin in health and disease
Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …
High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance
is largely unknown. Here, we show that lean mice become insulin resistant after being …
is largely unknown. Here, we show that lean mice become insulin resistant after being …
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
Objective Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor
expressed in tissues with high oxidative activity that plays a central role in metabolism. In …
expressed in tissues with high oxidative activity that plays a central role in metabolism. In …
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome
P Wang, H Sun, G Maitiabula, L Zhang, J Yang… - Nature …, 2023 - nature.com
Total parenteral nutrition (TPN) can lead to complications, such as glucose metabolism
disorders. While TPN is associated with impairments in intestinal function, the gut barrier …
disorders. While TPN is associated with impairments in intestinal function, the gut barrier …
Mechanisms of xenobiotic receptor activation: Direct vs. indirect
The so-called xenobiotic receptors (XRs) have functionally evolved into cellular sensors for
both endogenous and exogenous stimuli by regulating the transcription of genes encoding …
both endogenous and exogenous stimuli by regulating the transcription of genes encoding …
FGF21 in obesity and cancer: New insights
The endocrine FGF21 was discovered as a novel metabolic regulator in 2005 with new
functions bifurcating from the canonic heparin-binding FGFs that directly promote cell …
functions bifurcating from the canonic heparin-binding FGFs that directly promote cell …
Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy
K Zhu, Q Meng, Z Zhang, T Yi… - Molecular …, 2019 - spandidos-publications.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor originally
isolated and characterized as the dioxin or xenobiotic receptor. With the discovery of …
isolated and characterized as the dioxin or xenobiotic receptor. With the discovery of …
The aryl hydrocarbon receptor in liver inflammation
A Carambia, FA Schuran - Seminars in Immunopathology, 2021 - Springer
The aryl hydrocarbon receptor (AHR) is a ubiquitously expressed ligand-activated
transcription factor with multifaceted physiological functions. In the immune system, AHR has …
transcription factor with multifaceted physiological functions. In the immune system, AHR has …
The aryl hydrocarbon receptor in energy balance: the road from dioxin-induced wasting syndrome to combating obesity with ahr ligands
NG Girer, CR Tomlinson, CJ Elferink - International journal of molecular …, 2020 - mdpi.com
The aryl hydrocarbon receptor (AHR) has been studied for over 40 years, yet our
understanding of this ligand-activated transcription factor remains incomplete. Each year …
understanding of this ligand-activated transcription factor remains incomplete. Each year …