Nucleosidic and non-nucleosidic folate conjugates
AP Guzaev, PD Cook, M Manoharan, B Bhat - US Patent 6,335,434, 2002 - Google Patents
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Oligonucleotide-folate conjugates
PD Cook, M Manoharan, B Bhat - US Patent 6,528,631, 2003 - Google Patents
Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or
more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and …
more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and …
Nucleoside and oligonucleotide analogues
M Kaneko, K Morita, T Imanishi - US Patent 7,314,923, 2008 - Google Patents
US7314923B2 - Nucleoside and oligonucleotide analogues - Google Patents
US7314923B2 - Nucleoside and oligonucleotide analogues - Google Patents Nucleoside …
US7314923B2 - Nucleoside and oligonucleotide analogues - Google Patents Nucleoside …
System for targeted delivery of therapeutic agents
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M1kose1a1. 6,403,779 B1 6/2002 Kawasakl et al. 5,514,378 A 5/1996 M1koseta1 …
M1kose1a1. 6,403,779 B1 6/2002 Kawasakl et al. 5,514,378 A 5/1996 M1koseta1 …
Modified polynucleotides for reducing off-target effects in RNA interference
Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …
are provided The methods and compositions permit effective and efficient applications of …
Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 7,695,902, 2010 - Google Patents
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
Nucleoside and oligonucleotide analogues
M Kaneko, K Morita, T Imanishi - US Patent 7,335,765, 2008 - Google Patents
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Goodchild et al. 5,004,810 A 4/1991 Draper 5,166,195 A 11/1992 Ecker 5, 194428 A 3/1993 …
Delivery of Nanoparticles and/or Agents to Cells
2008-06-09 Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY reassignment
MASSACHUSETTS INSTITUTE OF TECHNOLOGY ASSIGNMENT OF ASSIGNORS …
MASSACHUSETTS INSTITUTE OF TECHNOLOGY ASSIGNMENT OF ASSIGNORS …
Compositions and methods for inhibiting expression of Huntingtin gene
DWY Sah, P Hadwiger, I Roehl, B Bramlage… - US Patent …, 2008 - Google Patents
2007-01-12 Assigned to ALNYLAM EUROPE AG reassignment ALNYLAM EUROPE AG
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
Compositions and methods for non-parenteral delivery of oligonucleotides
CL Teng, PD Cook, L Tillman, GE Hardee… - US Patent …, 2004 - Google Patents
US6747014B2 - Compositions and methods for non-parenteral delivery of oligonucleotides -
Google Patents US6747014B2 - Compositions and methods for non-parenteral delivery of …
Google Patents US6747014B2 - Compositions and methods for non-parenteral delivery of …