The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Nuclear processes such as DNA replication, transcription, and RNA processing each
depend on the concerted action of many different protein and RNA molecules. How …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Identification of post-translationally or chemically modified peptides in mass spectrometry-
based proteomics experiments is a crucial yet challenging task. We have recently introduced …

Eight types of short-chain Lys acylations have recently been identified on histones:
propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Metabolism and gene expression, which are two fundamental biological processes that are
essential to all living organisms, reciprocally regulate each other to maintain homeostasis …

Here we report the identification and verification of a β-hydroxybutyrate-derived protein
modification, lysine β-hydroxybutyrylation (Kbhb), as a new type of histone mark. Histone …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …