Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …

There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …

Protein kinases regulate the majority of signal transduction pathways in cells and have
become important targets for the development of designer drugs. We present a systematic …

The main complicating factor in structure-based drug design is receptor rearrangement upon
ligand binding (induced fit). It is the induced fit that complicates cross-docking of ligands …

2, 3-Dihydroquinazolin-4-one (DHQ) belongs to the class of nitrogen-containing heterocyclic
compounds representing a core structural component in various biologically active …

Mitogen-activated protein kinase p38 is a serine/threonine kinase originally isolated from
lipopolysaccharide (LPS) stimulated monocytes. There are four isoforms p38α, p38β, p38γ …

Introduction p38R is a member of the well characterized mitogen activated protein (MAPa)
kinase family of serine/threonine protein kinases. p38R is widely expressed in endothelial …

The quinazolinone and pyridol-pyrimidine classes of p38 MAP kinase inhibitors have a
previously unseen degree of specificity for p38 over other MAP kinases. Comparison of the …

In the past few years macromolecular crystallography has become a standard technique
used by many pharmaceutical and biotechnology companies. This methodology offers …

Ligand binding involves breakage of hydrogen bonds with water molecules and formation of
new hydrogen bonds between protein and ligand. In this work, the change of hydrogen …