Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

Marine organisms' persistence hinges on the capacity for acclimatization and adaptation to
the myriad of interacting environmental stressors associated with global climate change. In …

Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …

Nicotinamide N-methyltransferase (NNMT) is overexpressed in a variety of human cancers,
where it contributes to tumorigenesis by a mechanism that is still poorly understood. Here …

Abstract DNA methyltransferase 1 (DNMT1) is crucial for maintenance of methylation, gene
regulation and chromatin stability,,. DNA mismatch repair, cell cycle regulation in post-mitotic …

Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms
and enzymes remain unclear. Using zebrafish embryos we provide evidence for 5 …

Recent expansion of our knowledge on epigenetic changes strongly suggests that not only
nuclear DNA (nDNA), but also mitochondrial DNA (mtDNA) may be subjected to epigenetic …