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[HTML][HTML] The role of Rab proteins in Parkinson's disease synaptopathy
In patients affected by Parkinson's disease (PD), the most common neurodegenerative
movement disorder, the brain is characterized by the loss of dopaminergic neurons in the …
movement disorder, the brain is characterized by the loss of dopaminergic neurons in the …
The organizing principle of GABAB receptor complexes: Physiological and pharmacological implications
GABAB receptors (GBRs), the G protein‐coupled receptors for the neurotransmitter γ‐
aminobutyric acid (GABA), regulate synaptic transmission at most synapses in the brain …
aminobutyric acid (GABA), regulate synaptic transmission at most synapses in the brain …
Palmitoylation of the Parkinson's disease–associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis
Synaptotagmin-11 (Syt11) is a vesicle-trafficking protein that is linked genetically to
Parkinson's disease (PD). Likewise, the protein α-synuclein regulates vesicle trafficking, and …
Parkinson's disease (PD). Likewise, the protein α-synuclein regulates vesicle trafficking, and …
Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity
Abstract Synaptotagmin-11 (Syt11) is a Synaptotagmin isoform that lacks an apparent ability
to bind calcium, phospholipids, or SNARE proteins. While human genetic studies have …
to bind calcium, phospholipids, or SNARE proteins. While human genetic studies have …
Synaptotagmin‐11 inhibits cytokine secretion and phagocytosis in microglia
C Du, Y Wang, F Zhang, S Yan, Y Guan, X Gong… - Glia, 2017 - Wiley Online Library
Cytokine secretion and phagocytosis are key functions of activated microglia. However, the
molecular mechanisms underlying their regulation in microglia remain largely unknown …
molecular mechanisms underlying their regulation in microglia remain largely unknown …
Synaptotagmin-11 inhibits synaptic vesicle endocytosis via endophilin A1
Synaptic vesicle (SV) endocytosis is a critical and well-regulated process for the
maintenance of neurotransmission. We previously reported that synaptotagmin-11 (Syt11) …
maintenance of neurotransmission. We previously reported that synaptotagmin-11 (Syt11) …
Unveiling the significance of synaptic proteins in parkinson's pathogenesis: A review
Parkinson's disease (PD) is a progressive neurodegenerative disorder that leads to death of
dopaminergic neurons and deficiency of dopamine. It is the second most common …
dopaminergic neurons and deficiency of dopamine. It is the second most common …
Differences in MTHFR and LRRK2 variant's association with sporadic Parkinson's disease in Mexican Mestizos correlated to Native American ancestry
Abstract Parkinson's disease (PD), a common neurodegenerative disorder, has a complex
etiology where environmental and genetic factors intervene. While a number of genes and …
etiology where environmental and genetic factors intervene. While a number of genes and …
Synaptotagmin‐11 regulates the functions of caveolae and responds to mechanical stimuli in astrocytes
S Yan, Y Wang, Y Zhang, L Wang, X Zhao… - The FASEB …, 2020 - Wiley Online Library
Caveolae play crucial roles in intracellular membrane trafficking and mechanosensation. In
this study, we report that synaptotagmin‐11 (Syt11), a synaptotagmin isoform associated …
this study, we report that synaptotagmin‐11 (Syt11), a synaptotagmin isoform associated …
Synaptotagmin‐11 inhibits spontaneous neurotransmission through vti1a
Recent work has revealed that spontaneous release plays critical roles in the central
nervous system, but how it is regulated remains elusive. Here, we report that synaptotagmin …
nervous system, but how it is regulated remains elusive. Here, we report that synaptotagmin …