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Neuroimaging biomarkers for Alzheimer's disease
Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …
Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease
Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
In this study, we have assessed the validity and reliability of an automated labeling system
that we have developed for subdividing the human cerebral cortex on magnetic resonance …
that we have developed for subdividing the human cerebral cortex on magnetic resonance …
Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate
Memory decline in aging results from multiple factors that influence both executive function
and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems …
and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems …
A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability …
Atlas normalization, as commonly used by functional data analysis, provides an automated
solution to the widely encountered problem of correcting for head size variation in regional …
solution to the widely encountered problem of correcting for head size variation in regional …
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment
Functional magnetic resonance imaging (fMRI) studies have observed hyperactivity in the
hippocampal region in individuals with Mild Cognitive Impairment (MCI). However, the …
hippocampal region in individuals with Mild Cognitive Impairment (MCI). However, the …
Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance
The current study tested the accuracy of primary MRI and cerebrospinal fluid (CSF)
biomarker candidates and neuropsychological tests for predicting the conversion from mild …
biomarker candidates and neuropsychological tests for predicting the conversion from mild …
Map** hippocampal and ventricular change in Alzheimer disease
We developed an anatomical map** technique to detect hippocampal and ventricular
changes in Alzheimer disease (AD). The resulting maps are sensitive to longitudinal …
changes in Alzheimer disease (AD). The resulting maps are sensitive to longitudinal …
Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps
Background While most patients with mild cognitive impairment (MCI) transition to Alzheimer
disease (AD), others develop non-AD dementia, remain in the MCI state, or improve …
disease (AD), others develop non-AD dementia, remain in the MCI state, or improve …
Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging
We describe a new method to automatically discriminate between patients with Alzheimer's
disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on …
disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on …