Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

A substantial proportion of the genome of many species is derived from transposable
elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to …

The use of the human reference genome has shaped methods and data across modern
genomics. This has offered many benefits while creating a few constraints. In the following …

Significant innovations in next-generation sequencing techniques and bioinformatics tools
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …

Recent progress in deep learning has greatly improved the prediction of RNA splicing from
DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site …

Characterization of Human Endogenous Retrovirus (HERV) expression within the
transcriptomic landscape using RNA-seq is complicated by uncertainty in fragment …

By map** the positions of millions of translating ribosomes in the cell, ribosome profiling
(Ribo-seq) has established its role as a powerful tool to study gene expression. Several …

Many eukaryotic genomes harbour large numbers of duplicated sequences, of diverse
biotypes, resulting from several mechanisms including recombination, whole genome …

Constituents of multiprotein complexes are required at well-defined levels relative to each
other. However, it remains unknown whether eukaryotic cells typically produce precise …

Background Chromatin provides a tunable platform for gene expression control. Besides the
well-studied core nucleosome, H1 linker histones are abundant chromatin components with …