B cells have been known for their ability to present antigens to T cells for almost 40 years.
However, the precise roles of B cell antigen presentation in various immune responses are …

Publisher Summary This chapter attempts to identify the principles and issues elucidated in
animal models that may provide insights for the development of effective approaches to …

We investigated the antigen specificity and presentation requirements for inactivation of T
lymphocytes in vitro and in vivo. In vitro studies revealed that splenocytes treated with the …

The priming of tumor-antigen-specific T cells is critical for the initiation of successful anti-
tumor immune responses, yet the fate of such cells during tumor progression is unknown …

In the presence of antigen presenting cells, a murine T helper (Th) cell specific for murine
hemoglobin (Hb) responded to its immunogenic peptide by both cytokine (interleukin-4) …

There are three possible outcomes when a T cell recognizes a cell bearing a self or foreign
antigen.(i) The T cell is not sufficiently signaled and is unaffected.(ii) The T cell is …

Materials and Methods Mice. BALB/c mice, ages 6-12 wk, were purchased from Charles
River Breeding Laboratories, Inc., Kingston, NY or Cumberland Farms, Clinton, TN. Animals …

Combined treatment with allogeneic small lymphocytes or T-depleted small lymphocytes
plus a blocking antibody to CD40 ligand (CD40L) permitted indefinite pancreatic islet …

B lymphocytes are regarded as professional antigen-presenting cells (APCs) despite their
primary role in humoral immunity. Over the last two decades, studies designed to define the …

This addition to unit here will describe the assays needed to evaluate CD4· CD25· T cell non‐
responsiveness and function. Unlike the conventional T cells described in, CD4· CD25· cells …