Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Tendons are dense connective tissues with a hierarchical polarized structure that respond to
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …

To date, the cell and molecular mechanisms regulating tendon healing are poorly
understood. Here, we establish a novel model of tendon regeneration using neonatal mice …

How mechanical stress affects physical performance via tendons is not fully understood.
Piezo1 is a mechanosensitive ion channel, and E756del PIEZO1 was recently found as a …

Both acute and chronic tendinopathy result in high morbidity, requiring management that is
often lengthy and expensive. However, limited and conflicting scientific evidence …

Tendon formation and repair rely on specific combinations of transcription factors, growth
factors, and mechanical parameters that regulate the production and spatial organization of …

Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …

During embryogenesis, the musculoskeletal system develops while containing within itself a
force generator in the form of the musculature. This generator becomes functional relatively …

Tendons mainly function as load‐bearing tissues in the muscloskeletal system; transmitting
loads from muscle to bone. Tendons are dynamic structures that respond to the magnitude …