Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly
expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in …

Significance: The release of myeloperoxidase (MPO) by activated leukocytes is critical in
innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …

The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

The heme protein myeloperoxidase (MPO) is a major constituent of neutrophils. As a key
mediator of the innate immune system, neutrophils are rapidly recruited to inflammatory …

抄録 There is considerable interest in the role that mammalian heme peroxidase enzymes,
primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide …

Endothelial cells are covered by a delicate meshwork of glycoproteins known as the
glycocalyx. Under normophysiological conditions the glycocalyx plays an active role in …

Heme peroxidases are a major source of reactive oxidants at sites of inflammation in
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …

Significance: The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil
bactericidal proteins and is stored in large amounts inside azurophilic granules of …

Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It
is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement …

The pathophysiology of multiple sclerosis (MS) involves several components: redox,
inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by …