Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against
microorganisms. In the last decades, AMPs have become powerful alternative agents that …

Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

Antimicrobial resistance has become one of the greatest threats to public health, with rising
resistance to carbapenems being a particular concern due to the lack of effective and safe …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing
problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) …

Background Carbapenem resistance is defined as in vitro non-susceptibility to any
carbapenem and/or documented production of a carbapenemase. This feature has rapidly …

Polymyxins have been regarded as an efficient therapeutic against many life‐threatening,
multidrug resistant Gram‐negative bacterial infections; however, the cytotoxicity and …

Stem lettuce has a long history of cultivation in China and possesses high nutritional and
medicinal value. In our previous studies, extraction optimization, characterization, and …

The polymyxin and lipopeptide classes of antibiotics are membrane-targeting drugs of last
resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar …