Cocaine: an updated overview on chemistry, detection, biokinetics, and pharmacotoxicological aspects including abuse pattern

R Roque Bravo, AC Faria, AM Brito-da-Costa, H Carmo… - Toxins, 2022 - mdpi.com
Cocaine is one of the most consumed stimulants throughout the world, as official sources
report. It is a naturally occurring sympathomimetic tropane alkaloid derived from the leaves …

[HTML][HTML] Cocaine: an updated overview on chemistry, detection, biokinetics, and pharmacotoxicological aspects including abuse pattern

RR Bravo, AC Faria, AM Brito-da-Costa, H Carmo… - Toxins, 2022 - ncbi.nlm.nih.gov
Cocaine is one of the most consumed stimulants throughout the world, as official sources
report. It is a naturally occurring sympathomimetic tropane alkaloid derived from the leaves …

Repurposing ketamine to treat cocaine use disorder: Integration of artificial intelligence‐based prediction, expert evaluation, clinical corroboration and mechanism of …

Z Gao, TJ Winhusen, M Gorenflo, UE Ghitza… - …, 2023 - Wiley Online Library
Background and aims Cocaine use disorder (CUD) is a significant public health issue for
which there is no Food and Drug Administration (FDA) approved medication. Drug …

The fourth wave of the overdose crisis: Examining the prominent role of psychomotor stimulants with and without fentanyl

RA Rawson, TG Erath, HW Clark - Preventive Medicine, 2023 - Elsevier
The current overdose and broader public health crisis involving illicit drug use is often
referred to as the “opioid” or “fentanyl” crisis. Clearly there is extensive data on the profound …

Contingency management for drug use disorders: Meta-analysis and application of Tolin's criteria.

RA Pfund, MK Ginley, CL Boness, CJ Rash… - … Science and Practice, 2024 - psycnet.apa.org
Several professional organizations and federal agencies recommend contingency
management (CM) as an empirically supported treatment for drug use disorder. However …

Should contingency management protocols and dissemination practices be modified to accommodate rising stimulant use and harm reduction frameworks?

GK Khazanov, JR McKay, R Rawson - Addiction, 2024 - Wiley Online Library
Background Stimulant‐related overdoses have increased dramatically, with almost 50% of
overdoses in the United States now involving stimulants. Additionally, harm‐reduction …

Cocaine use disorder (CUD): current clinical perspectives

EKC Schwartz, NR Wolkowicz… - Substance Abuse and …, 2022 - Taylor & Francis
Cocaine use disorder (CUD) is a devastating disorder, impacting both individuals and
society. Individuals with CUD face many barriers in accessing treatment for CUD, and most …

Frame shift: focusing on harm reduction and shared decision making for people who use drugs hospitalized with infections

K Thakarar, A Appa… - Clinical Infectious …, 2024 - academic.oup.com
1Tufts University School of Medicine, Boston, Massachusetts, USA; 2Center for
Interdisciplinary Population & Health Research, MaineHealth Institute for Research …

Meta-review on the efficacy of psychological therapies for the treatment of substance use disorders

L Dellazizzo, S Potvin, S Giguère, C Landry… - Psychiatry …, 2023 - Elsevier
This meta-review aimed to summarize the current state of knowledge provided by meta-
analyzes on the efficacy of psychotherapies for substance use disorders. A systematic …

Modifications to 1-(4-(2-Bis (4-fluorophenyl) methyl) sulfinyl) alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

AV Okorom, GA Camacho-Hernandez… - Journal of medicinal …, 2023 - ACS Publications
Atypical dopamine transporter (DAT) inhibitors have shown therapeutic potential in the
preclinical models of psychostimulant use disorders (PSUD). In rats, 1-(4-(2-((bis (4 …