Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

The physiological heterogeneity of platelets leads to diverse responses and the formation of
discrete subpopulations upon platelet stimulation. Procoagulant platelets are an example of …

Platelets play a key role in maintaining hemostasis. However, dysregulated platelet
activation can lead to pathological thrombosis or bleeding. Once a platelet gets activated, it …

The leading cause of heart disease in developed countries is coronary atherosclerosis,
which is not simply a result of ageing but a chronic inflammatory process that can lead to …

Dysregulated platelet functions contribute to the development and progression of ischemic
stroke. Utilizing mice with a platelet-specific deletion of cyclophilin D (CypD), a mediator of …

The high occurrence of cancer-associated thrombosis is associated with elevated thrombin
generation. Tumour cells increase the potential for thrombin generation both directly …

Platelets are key players in cardiovascular disease, and platelet aggregation represents a
central pharmacologic target, particularly in secondary prevention. However, inhibition of …

Exercise training is associated with an acute net increase in coagulation, which may
increase the risk of atherothrombosis in coronary artery disease (CAD) patients. We sought …

BACKGROUND: Single-nucleotide polymorphisms linked with the rs1474868 T allele
(MFN2 [mitofusin-2] T/T) in the human mitochondrial fusion protein MFN2 gene are …

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe prothrombotic
complication of adenoviral vaccines, including the ChAdOx1 nCoV-19 (Vaxzevria) vaccine …