Ovarian damage from chemotherapy and current approaches to its protection

N Spears, F Lopes, A Stefansdottir… - Human reproduction …, 2019 - academic.oup.com
Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

[HTML][HTML] Is melatonin the “next vitamin D”?: a review of emerging science, clinical uses, safety, and dietary supplements

DM Minich, M Henning, C Darley, M Fahoum… - Nutrients, 2022 - mdpi.com
Nutrients | Free Full-Text | Is Melatonin the “Next Vitamin D”?: A Review of
Emerging Science, Clinical Uses, Safety, and Dietary Supplements Next Article in Journal …

Melatonin and its ubiquitous anticancer effects

S Bhattacharya, KK Patel, D Dehari, AK Agrawal… - Molecular and cellular …, 2019 - Springer
Abstract Melatonin (N-acetyl-5-methoxy-tryptamine), which is generally considered as
pleiotropic and multitasking molecule, secretes from pineal gland at night under normal light …

Endocrine disrupting chemicals in polycystic ovary syndrome: the relevant role of the theca and granulosa cells in the pathogenesis of the ovarian dysfunction

M Jozkowiak, H Piotrowska-Kempisty, D Kobylarek… - Cells, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder
among women of reproductive age. The pathogenesis of PCOS remains elusive; however …

Long‐term melatonin treatment delays ovarian aging

H Tamura, M Kawamoto, S Sato… - Journal of Pineal …, 2017 - Wiley Online Library
Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin
is considered an anti‐aging agent due to its cytoprotective actions as an antioxidant. This …

[HTML][HTML] Melatonin and the circadian system: contributions to successful female reproduction

RJ Reiter, H Tamura, DX Tan, XY Xu - Fertility and sterility, 2014 - Elsevier
Objective To summarize the role of melatonin and circadian rhythms in determining optimal
female reproductive physiology, especially at the peripheral level. Design Databases were …

[PDF][PDF] Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage

Y Guo, L Xue, W Tang, J **ong, D Chen… - Human …, 2024 - academic.oup.com
BACKGROUND Chemotherapy-associated ovarian damage (CAOD) is one of the most
feared short-and long-term side effects of anticancer treatment in premenopausal women …

Impact of early nutrition, physical activity and sleep on the fetal programming of disease in the pregnancy: a narrative review

J Moreno-Fernandez, JJ Ochoa, M Lopez-Frias… - Nutrients, 2020 - mdpi.com
Early programming is the adaptation process by which nutrition and environmental factors
alter development pathways during prenatal growth, inducing changes in postnatal …

Melatonin prevents cisplatin‐induced primordial follicle loss via suppression of PTEN/AKT/FOXO 3a pathway activation in the mouse ovary

H Jang, OH Lee, Y Lee, H Yoon… - Journal of pineal …, 2016 - Wiley Online Library
Premature ovarian failure (POF) is a major side effect of chemotherapy in young cancer
patients. To develop pharmaceutical agents for preserving fertility, it is necessary to …

Melatonin promotes uterine and placental health: potential molecular mechanisms

LG de Almeida Chuffa, LA Lupi, MS Cucielo… - International journal of …, 2019 - mdpi.com
The development of the endometrium is a cyclic event tightly regulated by hormones and
growth factors to coordinate the menstrual cycle while promoting a suitable …