Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Polymyxins are a class of antibiotics that were discovered in 1947 from programs searching
for compounds effective in the treatment of Gram-negative infections. Produced by the Gram …

Gram-positive Enterococcus faecium exhibited higher susceptibility (> 4-fold) to polymyxin B
(PMB), the canonical antimicrobial peptide against Gram-negative bacteria, under anaerobic …

Polymyxins are often the only effective antibiotics against the" Critical" pathogen
Acinetobacter baumannii. Worryingly, highly polymyxin-resistant A. baumannii displaying …

Combination therapy provides a useful therapeutic approach to overcome resistance until
new antibiotics become available. In this study, the pharmacodynamics, including the …

This study aimed at investigating the antibacterial activity of aspidinol, an extract from
Dryopteris fragrans (L.) Schott, against methicillin-resistant Staphylococcus aureus (MRSA) …

Listeria monocytogenes, a pathogenic bacterium causing zoonotic diseases, necessitates
the urgent search for novel anti-Listeria monocytogenes drugs due to the continuous …

Water activity (aw) and heating rates are two major factors altering heat resistance of food-
borne pathogens. The specific mechanism of heat resistance triggered by these two factors …

Our previous studies revealed the existence of a Universal Receptive System that regulates
interactions between cells and their environment. This system is composed of DNA-and …

In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives was designed,
synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic …