mRNA vaccines for infectious diseases: principles, delivery and clinical translation
N Chaudhary, D Weissman… - Nature reviews Drug …, 2021 - nature.com
Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
A comprehensive review of mRNA vaccines
mRNA vaccines have been demonstrated as a powerful alternative to traditional
conventional vaccines because of their high potency, safety and efficacy, capacity for rapid …
conventional vaccines because of their high potency, safety and efficacy, capacity for rapid …
[HTML][HTML] COVID-19 in pregnancy: implications for fetal brain development
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
during pregnancy on the develo** fetal brain is poorly understood. Other antenatal …
during pregnancy on the develo** fetal brain is poorly understood. Other antenatal …
Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses
There is a persistent bias toward higher prevalence and increased severity of coronavirus
disease 2019 (COVID-19) in males. Underlying mechanisms accounting for this sex …
disease 2019 (COVID-19) in males. Underlying mechanisms accounting for this sex …
Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against …
JR Barbosa, RN de Carvalho Junior - Trends in food science & technology, 2021 - Elsevier
Background The global crisis caused by the outbreak of severe acute respiratory syndrome
caused by the SARS-CoV-2 virus, better known as COVID-19, brought the need to improve …
caused by the SARS-CoV-2 virus, better known as COVID-19, brought the need to improve …
Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface
Background Pregnant women are at increased risk for severe outcomes from coronavirus
disease 2019 (COVID-19), but the pathophysiology underlying this increased morbidity and …
disease 2019 (COVID-19), but the pathophysiology underlying this increased morbidity and …
Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition
Individuals with Down syndrome (DS) display chronic hyperactivation of interferon signaling.
However, the clinical impacts of interferon hyperactivity in DS are ill-defined. Here, we …
However, the clinical impacts of interferon hyperactivity in DS are ill-defined. Here, we …
Understanding early-life adaptive immunity to guide interventions for pediatric health
Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …
Innate immune responses to acute viral infection during pregnancy
Immunological adaptations in pregnancy allow maternal tolerance of the semi-allogeneic
fetus but also increase maternal susceptibility to infection. At implantation, the endometrial …
fetus but also increase maternal susceptibility to infection. At implantation, the endometrial …
Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS‐CoV‐2s
AP Mahyuddin, A Kanneganti, JJL Wong… - Prenatal …, 2020 - Wiley Online Library
There remain unanswered questions concerning mother‐to‐child‐transmission of SARS‐
CoV‐2. Despite reports of neonatal COVID‐19, SARS‐CoV‐2 has not been consistently …
CoV‐2. Despite reports of neonatal COVID‐19, SARS‐CoV‐2 has not been consistently …