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[HTML][HTML] The NLRP3 inflammasome in depression: potential mechanisms and therapies
CY **a, YX Guo, WW Lian, Y Yan, BZ Ma… - Pharmacological …, 2023 - Elsevier
Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …
Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify …
A combination of different risk factors, such as genetic, environmental and psychological
factors, together with immune system, stress response, brain neuroplasticity and the …
factors, together with immune system, stress response, brain neuroplasticity and the …
Toll-like receptor signaling in depression
Depression is one of the most prevalent, disabling, and costly mental illnesses currently
affecting over 300 million people worldwide. A subset of depressed patients display …
affecting over 300 million people worldwide. A subset of depressed patients display …
Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases
The innate immunity is a stereotyped first line of defense against pathogens and unspecified
damage signals. One of main actors of innate immunity are the Toll-like receptors (TLRs) …
damage signals. One of main actors of innate immunity are the Toll-like receptors (TLRs) …
Toll-like receptors 2,-3 and-4 prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1β release
L Facci, M Barbierato, C Marinelli, C Argentini… - Scientific reports, 2014 - nature.com
Abstract Interleukin-1β (IL-1β) is a crucial mediator in the pathogenesis of inflammatory
diseases at the periphery and in the central nervous system (CNS). Produced as an …
diseases at the periphery and in the central nervous system (CNS). Produced as an …
Exploring the role of inflammation in major depressive disorder: beyond the monoamine hypothesis
Major depressive disorder affects approximately 8.4% of the United States population. The
World Health Organization estimates that 280 million adults worldwide are suffering from …
World Health Organization estimates that 280 million adults worldwide are suffering from …
Association between toll-like receptors expression and major depressive disorder
Accumulating evidences suggest that Toll-like receptors (TLRs) were involved in the
pathophysiology of major depressive disorder. TLR4 was thought to be associated with …
pathophysiology of major depressive disorder. TLR4 was thought to be associated with …
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management
Neuropsychiatric disorders denote a broad range of illnesses involving neurology and
psychiatry. These disorders include depressive disorders, anxiety, schizophrenia, bipolar …
psychiatry. These disorders include depressive disorders, anxiety, schizophrenia, bipolar …
Maternal deprivation increases microglial activation and neuroinflammatory markers in the prefrontal cortex and hippocampus of infant rats
A relationship between neuroinflammation and the development of psychiatric disorder have
been revealed by many studies in the past decade. Although studies have shown that …
been revealed by many studies in the past decade. Although studies have shown that …
Association between toll-like receptor 4 expression and symptoms of major depressive disorder
MK Wu, TL Huang, KW Huang, YL Huang… - … disease and treatment, 2015 - Taylor & Francis
Background In our previous study, toll-like receptor 4 (TLR4) mRNA expression level was
associated with severity of major depressive disorder (MDD) evaluated with the 17-item …
associated with severity of major depressive disorder (MDD) evaluated with the 17-item …