Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …

Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …

Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …

Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Abstract Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a widely
studied lncRNA in cancer. Although dispensable for normal physiology, MALAT1 is …