[HTML][HTML] Intravitreal hydrogels for sustained release of therapeutic proteins
This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …
the posterior segment of the eye in order to increase therapeutic outcome and patient …
In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations
H Almeida, MH Amaral, P Lobão, JMS Lobo - Drug discovery today, 2014 - Elsevier
The low therapeutic efficacy exhibited by conventional ophthalmic solutions owing to
precorneal elimination of the drug, drainage by gravity, nasolacrimal drainage, conjunctival …
precorneal elimination of the drug, drainage by gravity, nasolacrimal drainage, conjunctival …
In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery
K Al Khateb, EK Ozhmukhametova, MN Mussin… - International journal of …, 2016 - Elsevier
This study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating
in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in …
in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in …
Chitosan-based in situ gels for ocular delivery of therapeutics: a state-of-the-art review
Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye
drops because they associate the advantages of solutions such as accuracy and …
drops because they associate the advantages of solutions such as accuracy and …
In situ gel systems as 'smart' carriers for sustained ocular drug delivery
Introduction: In situ gel systems refer to a class of novel delivery vehicles, composed of
natural, semisynthetic or synthetic polymers, which present the unique property of sol–gel …
natural, semisynthetic or synthetic polymers, which present the unique property of sol–gel …
Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye–Part I–Barriers and determining factors in ocular delivery
E Sánchez-López, M Espina, S Doktorovova… - European Journal of …, 2017 - Elsevier
Ocular drug delivery is still a challenge for researchers in the field of pharmaceutical
technology due to anatomical and physiological eye characteristics. The tissue barriers …
technology due to anatomical and physiological eye characteristics. The tissue barriers …
Optimizing the chitosan-cellulose based drug delivery system for controlling the ciprofloxacin release versus organic/inorganic crosslinker, characterization and kinetic …
VF Lotfy, AH Basta - International Journal of Biological Macromolecules, 2020 - Elsevier
This work was done to optimize the drug delivery system based on N-trimethyl chitosan
(TMC) and carboxylate-containing cellulose derivatives, as well as assessment the effective …
(TMC) and carboxylate-containing cellulose derivatives, as well as assessment the effective …
Applications of poloxamers in ophthalmic pharmaceutical formulations: an overview
H Almeida, MH Amaral, P Lobão… - Expert opinion on drug …, 2013 - Taylor & Francis
Introduction: An ideal ophthalmic formulation is one that not only prolongs the contact time of
the vehicle on the ocular surface but also slows down the drug elimination. The poor …
the vehicle on the ocular surface but also slows down the drug elimination. The poor …
Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis
The current study reports the development of bigels using sorbitan monostearate-sesame oil
organogel and carbopol 934 hydrogel. The microstructures and physicochemical properties …
organogel and carbopol 934 hydrogel. The microstructures and physicochemical properties …
Lamotrigine-loaded poloxamer-based thermo-responsive sol–gel: formulation, in vitro assessment, ex vivo permeation, and toxicology study
The present study aimed to prepare, characterize, and evaluate a thermo-responsive sol–
gel for intranasal delivery of lamotrigine (LTG), which was designed for sustained drug …
gel for intranasal delivery of lamotrigine (LTG), which was designed for sustained drug …