This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …

The low therapeutic efficacy exhibited by conventional ophthalmic solutions owing to
precorneal elimination of the drug, drainage by gravity, nasolacrimal drainage, conjunctival …

This study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating
in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in …

Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye
drops because they associate the advantages of solutions such as accuracy and …

This work was done to optimize the drug delivery system based on N-trimethyl chitosan
(TMC) and carboxylate-containing cellulose derivatives, as well as assessment the effective …

Ocular drug delivery is still a challenge for researchers in the field of pharmaceutical
technology due to anatomical and physiological eye characteristics. The tissue barriers …

Introduction: In situ gel systems refer to a class of novel delivery vehicles, composed of
natural, semisynthetic or synthetic polymers, which present the unique property of sol–gel …

Introduction: An ideal ophthalmic formulation is one that not only prolongs the contact time of
the vehicle on the ocular surface but also slows down the drug elimination. The poor …

The current study reports the development of bigels using sorbitan monostearate-sesame oil
organogel and carbopol 934 hydrogel. The microstructures and physicochemical properties …

The present study aimed to prepare, characterize, and evaluate a thermo-responsive sol–
gel for intranasal delivery of lamotrigine (LTG), which was designed for sustained drug …