[HTML][HTML] Multipotent stromal cells: one name, multiple identities
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …
regeneration of most tissues. They can differentiate along multiple connective lineages, but …
Lymph node stromal cells: cartographers of the immune system
AT Krishnamurty, SJ Turley - Nature immunology, 2020 - nature.com
Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …
Cross-tissue organization of the fibroblast lineage
Fibroblasts are non-haematopoietic structural cells that define the architecture of organs,
support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer …
support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer …
Single-cell RNA sequencing of lymph node stromal cells reveals niche-associated heterogeneity
Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the
immune response. However, the full diversity of lymph node (LN) SCs remains undefined …
immune response. However, the full diversity of lymph node (LN) SCs remains undefined …
Adventitial stromal cells define group 2 innate lymphoid cell tissue niches
MW Dahlgren, SW Jones, KM Cautivo, A Dubinin… - immunity, 2019 - cell.com
Type 2 lymphocytes promote both physiologic tissue remodeling and allergic pathology, yet
their physical tissue niches are poorly described. Here, we used quantitative imaging to …
their physical tissue niches are poorly described. Here, we used quantitative imaging to …
[HTML][HTML] Follicular dendritic cells restrict interleukin-4 availability in germinal centers and foster memory B cell generation
B cells within germinal centers (GCs) enter cycles of antibody affinity maturation or exit the
GC as memory cells or plasma cells. Here, we examined the contribution of interleukin (IL)-4 …
GC as memory cells or plasma cells. Here, we examined the contribution of interleukin (IL)-4 …
Lymph node fibroblastic reticular cells in health and disease
Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs)—
immunologically specialized myofibroblasts found in lymphoid tissue—has promoted these …
immunologically specialized myofibroblasts found in lymphoid tissue—has promoted these …
Tertiary lymphoid structures in cancer: drivers of antitumor immunity, immunosuppression, or bystander sentinels in disease?
EJ Colbeck, A Ager, A Gallimore… - Frontiers in immunology, 2017 - frontiersin.org
Secondary lymphoid organs are integral to initiation and execution of adaptive immune
responses. These organs provide a setting for interactions between antigen-specific …
responses. These organs provide a setting for interactions between antigen-specific …
Single-cell survey of human lymphatics unveils marked endothelial cell heterogeneity and mechanisms of homing for neutrophils
Lymphatic vessels form a critical component in the regulation of human health and disease.
While their functional significance is increasingly being recognized, the comprehensive …
While their functional significance is increasingly being recognized, the comprehensive …
Spatial transcriptomics combined with single‐cell RNA‐sequencing unravels the complex inflammatory cell network in atopic dermatitis
Y Mitamura, M Reiger, J Kim, Y **ao, D Zhakparov… - Allergy, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease
with complex pathogenesis for which the cellular and molecular crosstalk in AD skin has not …
with complex pathogenesis for which the cellular and molecular crosstalk in AD skin has not …