Membrane-less organelles are cellular structures which arise through the phenomenon of
phase separation. This process enables compartmentalization of specific sets of …

Combined experimental and computational studies of lipid membranes and liposomes, with
the aim to attain mechanistic understanding, result in a synergy that makes possible the …

UTX (also known as KDM6A) encodes a histone H3K27 demethylase and is an important
tumour suppressor that is frequently mutated in human cancers. However, as the …

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

Dendritic cell (DC) vaccine was among the first FDA-approved cancer immunotherapies, but
has been limited by the modest cytotoxic T lymphocyte (CTL) response and therapeutic …

Repeat expansion in the C9orf72 gene is the most common cause of the neurodegenerative
disorder amyotrophic lateral sclerosis (C9-ALS) and is linked to the unconventional …

Telomeres form unique nuclear compartments that prevent degradation and fusion of
chromosome ends by recruiting shelterin proteins and regulating access of DNA damage …

It remains unknown if biophysical or material properties of biomolecular condensates
regulate cancer. Here we show that AKAP95, a nuclear protein that regulates transcription …

Ribonucleoprotein (RNP) granules are membraneless liquid condensates that dynamically
form, dissolve, and mature into a gel-like state in response to a changing cellular …

Integrating biological imaging into early stages of the drug discovery process can provide
invaluable readouts of drug activity within complex disease settings, such as cancer …