[HTML][HTML] The forefront of ovarian cancer therapy: update on PARP inhibitors
MR Mirza, RL Coleman, A González-Martín… - Annals of …, 2020 - Elsevier
Background In recurrent ovarian cancer, poly (ADP-ribose) polymerase (PARP)-inhibiting
agents have transformed the treatment of platinum-sensitive disease. New data support use …
agents have transformed the treatment of platinum-sensitive disease. New data support use …
[HTML][HTML] Metal-and metalloid-based compounds to target and reverse cancer multidrug resistance
Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …
stage of the disease. However, based on their versatile chemistry, metal and metalloid …
Pan-cancer landscape of homologous recombination deficiency
Homologous recombination deficiency (HRD) results in impaired double strand break repair
and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar …
and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar …
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity
Detecting mutations from single DNA molecules is crucial in many fields but challenging.
Next-generation sequencing (NGS) affords tremendous throughput but cannot directly …
Next-generation sequencing (NGS) affords tremendous throughput but cannot directly …
The genomic and transcriptional landscape of primary central nervous system lymphoma
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …
Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers
Abstract Analysis of mutational signatures can reveal underlying molecular mechanisms of
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …
Genomic features and classification of homologous recombination deficient pancreatic ductal adenocarcinoma
Background and Aims Homologous recombination deficiency (HRD) in pancreatic ductal
adenocarcinoma (PDAC), remains poorly defined beyond germline (g) alterations in …
adenocarcinoma (PDAC), remains poorly defined beyond germline (g) alterations in …
Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer
The homologous recombination deficiency (HRD) score integrates three DNA-based
measures of genomic instability, and has been understudied in prostate cancer. Given the …
measures of genomic instability, and has been understudied in prostate cancer. Given the …
[HTML][HTML] Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase ζ and PRIMPOL
Z Gyüre, Á Póti, E Németh, B Szikriszt, R Lózsa… - Cell Reports, 2023 - cell.com
Translesion DNA synthesis (TLS) facilitates replication over damaged or difficult-to-replicate
templates by employing specialized DNA polymerases. We investigate the effect on …
templates by employing specialized DNA polymerases. We investigate the effect on …
Homologous recombination repair gene mutations to predict olaparib plus bevacizumab efficacy in the first-line ovarian cancer PAOLA-1/ENGOT-ov25 trial
E Pujade-Lauraine, J Brown, A Barnicle… - JCO Precision …, 2023 - ascopubs.org
PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for
newly diagnosed advanced high-grade ovarian cancer demonstrated a significant …
newly diagnosed advanced high-grade ovarian cancer demonstrated a significant …