Adolescence is a developmental period when physical and cognitive abilities are optimized,
when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal …

With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

p300 and CREB-binding protein (CBP) are ubiquitously expressed pleiotropic lysine
acetyltransferases and play a key role as transcriptional co-activators that are essential for a …

Neurodegenerative diseases are linked to the accumulation of specific protein aggregates,
suggesting an intimate connection between injured brain and loss of proteostasis …

The Rubinstein-Taybi syndrome (RSTS) is a rare congenital developmental disorder
characterized by a typical facial dysmorphism, distal limb abnormalities, intellectual …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …

Accumulation of senescent cells during aging contributes to chronic inflammation and age-
related diseases. While senescence is associated with profound alterations of the …