Formation, signaling and occurrence of specialized pro-resolving lipid mediators—what is the evidence so far?
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
NK Singh, GN Rao - Progress in lipid research, 2019 - Elsevier
lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …
The biosynthesis of enzymatically oxidized lipids
AA Hajeyah, WJ Griffiths, Y Wang, AJ Finch… - Frontiers in …, 2020 - frontiersin.org
Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …
signaling mediators and hormones, regulating various cellular and physiological processes …
[HTML][HTML] Formation of lipoxins and resolvins in human leukocytes
Specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins are formed by
the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic …
the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic …
A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis
Retinoic acid–related orphan receptor α (RORα) is considered a key regulator of
polarization in liver macrophages that is closely related to nonalcoholic steatohepatitis …
polarization in liver macrophages that is closely related to nonalcoholic steatohepatitis …
Regulation and functions of 15-lipoxygenases in human macrophages
RG Snodgrass, B Brüne - Frontiers in pharmacology, 2019 - frontiersin.org
Lipoxygenases (LOXs) catalyze the stereo-specific peroxidation of polyunsaturated fatty
acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages …
acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages …
[HTML][HTML] Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome
M Werner, PM Jordan, E Romp, A Czapka… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Nonsteroidal anti-inflammatory drugs interfere with the metabolism of arachidonic acid to
proinflammatory prostaglandins and leukotrienes by targeting cyclooxygenases (COXs), 5 …
proinflammatory prostaglandins and leukotrienes by targeting cyclooxygenases (COXs), 5 …
Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolution
Z Rao, E Brunner, B Giszas… - Proceedings of the …, 2023 - National Acad Sciences
Glucocorticoids (GC) are potent anti-inflammatory agents, broadly used to treat acute and
chronic inflammatory diseases, eg, critically ill COVID-19 patients or patients with chronic …
chronic inflammatory diseases, eg, critically ill COVID-19 patients or patients with chronic …
Development of a quantitative proteomics approach for cyclooxygenases and lipoxygenases in parallel to quantitative oxylipin analysis allowing the comprehensive …
NM Hartung, M Mainka, R Pfaff, M Kuhn… - Analytical and …, 2023 - Springer
Oxylipins derived from the cyclooxygenase (COX) and lipoxygenase (LOX) pathways of the
arachidonic acid (ARA) cascade are essential for the regulation of the inflammatory …
arachidonic acid (ARA) cascade are essential for the regulation of the inflammatory …
The octadecanoids: an emerging class of lipid mediators
A Quaranta, J Revol-Cavalier… - Biochemical Society …, 2022 - portlandpress.com
Oxylipins are enzymatic and non-enzymatic metabolites of mono-or polyunsaturated fatty
acids that encompass potent lipid mediators including the eicosanoids and docosanoids …
acids that encompass potent lipid mediators including the eicosanoids and docosanoids …