Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

The tumor immune microenvironment is a determinant of response to cancer
immunotherapy and, in many cases, is prognostic for patient survival independently of the …

CD8+ T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite
this, the developmental biology of exhausted CD8+ T cells (Tex) remains poorly defined …

Radiotherapy, a mainstay of first‐line cancer treatment, suffers from its high‐dose radiation‐
induced systemic toxicity and radioresistance caused by the immunosuppressive tumor …

Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …

Alterations in gut microbiota impact the pathophysiology of several diseases, including
cancer. Radiotherapy (RT), an established curative and palliative cancer treatment, exerts …

Purpose: In the proper context, radiotherapy can promote antitumor immunity. It is unknown
if elective nodal irradiation (ENI), a strategy that irradiates tumor-associated draining lymph …

Although radiotherapy has been used for over a century to locally control tumor growth,
alone it rarely induces an abscopal response or systemic antitumor immunity capable of …

Decades of advancements in immuno-oncology have enabled the development of current
immunotherapies, which provide long-term treatment responses in certain metastatic cancer …

Transforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ
excludes immune cells from tumors, and TGFβ inhibition improves the efficacy of cytotoxic …