Proteins are the working horse of the cellular machinery. They are responsible for diverse
functions ranging from molecular motors to signaling. They catalyze reactions, transport …

The carbonic anhydrases enzymes (CAs, EC 4.2. 1.1) are zinc containing metalloproteins,
which efficiently catalyse the reversible conversion of carbon dioxide to bicarbonate and …

Most proteins fold into 3D structures that determine how they function and orchestrate the
biological processes of the cell. Recent developments in computational methods for protein …

We discuss basic physical–chemical principles underlying the formation of stable
macromolecular complexes, which in many cases are likely to be the biological units …

Protein–protein interactions play key roles in many cellular processes and their affinities and
specificities are finely tuned to the functions they perform. Here, we present a study on the …

A new version of the popular software PISA for the analysis of macromolecular interfaces
and identification of biological assemblies (complexes) from macromolecular crystal …

Protein–protein complexes that dissociate and associate readily, often depending on the
physiological condition or environment, play an important role in many biological processes …

Protein–protein recognition plays an essential role in structure and function. Specific non-
covalent interactions stabilize the structure of macromolecular assemblies, exemplified in …

Tyrosinase is a member of the type 3 copper enzyme family that is involved in the production
of melanin in a wide range of organisms. The crystal structures of a tyrosinase from Bacillus …

The assumption that crystal contacts reflect natural macromolecular interactions makes a
basis for many studies in structural biology. However, the crystal state may correspond to a …