The atomistic change of C (sp3)–H to C (sp3)–O can have a profound impact on the physical
and biological properties of small molecules. Traditionally, chemical synthesis has relied on …

The various applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical
and life sciences demand a range of methods for their installation in an array of molecular …

This Perspective presents the fundamental principles, the elementary reactions, the initial
catalytic systems, and the contemporary catalysts that have converted C–H bond …

The alkyl group is the most common component of organic molecules and the most difficult
to selectively functionalize. The development of catalysts for dehydrogenation of alkyl …

An isolated Csingle bondH bond in a molecule has a very low reactivity owing to the large
kinetic barrier associated to the Csingle bondH bond cleavage and the apolar nature of this …

In spite of its large availability in natural or shale gas deposits, the use of methane in the
chemical industry as feedstock from a synthetic point of view yet constitutes a challenge in …

The formation of a single product from terminal functionalization of linear alkanes from a
transition metal–catalyzed reaction is reported. The rhodium complex Cp* Rh (η4 …

Hydrocarbons are readily available from inexpensive petrochemical and natural gas
feedstock and have been utilized as raw materials for the production of materials and energy …

hemistry is the science about breaking and forming of bonds between atoms. One of the
most important processes for organic chemistry is breaking bonds C–H, as well as C–C in …

The title topic is reviewed with emphasis on catalysis and on recent advances. Alkane σ
complexes, Shilov chemistry and oxidative addition routes are covered. Attention is also …